Opana ER 40mg works by binding to opioid receptors in the brain This blocks pain signals from reaching the brain, which reduces the feeling of pain Acetaminophen also helps to reduce pain, but it does not work in the same way as hydrocodone. Opana 40 is typically taken orally, and it starts to work within 30 minutes The effects of Opana 40mg pills can last for up to 4 hours.
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